N-silyl-tethered radical cyclizations: a new synthesis of gamma-amino alcohols

Org Lett. 2003 Apr 17;5(8):1341-4. doi: 10.1021/ol034288j.

Abstract

[reaction: see text] Various allylic and propargylic amines bearing a protecting group (PG) have been employed in N-silyl-tethered radical cyclizations. The resulting silapyrrolidine adducts could be smoothly oxidized, creating access to gamma-amino alcohols. The silylation, radical cyclization, and oxidation reactions could be consolidated in a one-pot process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allylamine / chemistry
  • Amino Alcohols / chemical synthesis*
  • Cyclization
  • Organosilicon Compounds / chemistry*
  • Oxidation-Reduction
  • Pyrrolidines / chemistry

Substances

  • Amino Alcohols
  • Organosilicon Compounds
  • Pyrrolidines
  • Allylamine