Abstract
An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apolipoprotein A-I / genetics
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Apolipoprotein A-I / metabolism*
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Apolipoproteins C / genetics
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Apolipoproteins C / metabolism*
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Carcinoma, Hepatocellular
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Hepatitis B virus / pathogenicity*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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RNA, Viral / genetics
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RNA, Viral / metabolism
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Tumor Cells, Cultured
Substances
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Apolipoprotein A-I
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Apolipoproteins C
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RNA, Messenger
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RNA, Viral