Abstract
A renal transplant recipient became persistently positive for hepatitis B virus (HBV) despite preexisting anti-hepatitis B surface (HBs) antibodies. The antigenicity and immunogenicity of wild-type (wt) and mutant HBs antigens (Ags) were compared. In contrast to wt HBsAg, genetic vaccination with mutant HBsAgs did not induce anti-HBs. Thus, mutations within HBsAg may enable HBV to escape immunological control.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Hepatitis Antibodies / immunology*
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Hepatitis B / immunology*
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Hepatitis B / virology*
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Hepatitis B Surface Antigens / genetics*
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Hepatitis B Surface Antigens / immunology*
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Hepatitis B Vaccines / immunology
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Hepatitis B virus / genetics*
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Hepatitis B virus / immunology
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Hepatitis B virus / physiology*
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Humans
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Kidney
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Kidney Transplantation*
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Mice
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Mutation
Substances
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Hepatitis Antibodies
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Hepatitis B Surface Antigens
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Hepatitis B Vaccines