Altered gravity modulates prostaglandin H synthase in human K562 cells

M Maccarrone; M Bari; T Lorenzon; A Finazzi-Agrò

Altered gravity modulates prostaglandin H synthase in human K562 cells

J Gravit Physiol. 2000 Jul;7(2):P61-2.

Authors

M Maccarrone¹, M Bari, T Lorenzon, A Finazzi-Agrò

Affiliation

¹ Department of Experimental Medicine and Biochemical Sciences and Biomedical Space Center, University of Rome, "Tor Vergata", Rome, Italy.

PMID: 12697532

Abstract

In this study, we extended our previous observations on the effects of altered gravity on the "lipoxygenase pathway", by ascertain the possible role of the force of gravity in modulating the activity and expression of PHS in human erythro-leukemia K562 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arachidonate 5-Lipoxygenase / metabolism
Centrifugation
Gene Expression Regulation
Gravity, Altered*
Humans
Hypergravity*
K562 Cells / enzymology*
Lymphocyte Activation / physiology
Prostaglandin-Endoperoxide Synthases / metabolism*
Rotation
Weightlessness Simulation*

Substances

Arachidonate 5-Lipoxygenase
Prostaglandin-Endoperoxide Synthases