Abstract
Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Gene Expression Regulation
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Glucocorticoids / metabolism
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Glucose / metabolism
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Hormones, Ectopic / genetics*
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Hormones, Ectopic / physiology*
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Hypoglycemic Agents / therapeutic use
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Insulin / metabolism
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Intercellular Signaling Peptides and Proteins*
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Ligands
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Mice
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Molecular Sequence Data
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NIH 3T3 Cells
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Nerve Growth Factor
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Obesity / genetics
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Protein Structure, Tertiary
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Proteins*
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Resistin
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Sequence Homology, Amino Acid
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Thiazolidinediones / therapeutic use
Substances
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Glucocorticoids
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Hormones, Ectopic
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Hypoglycemic Agents
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Insulin
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Intercellular Signaling Peptides and Proteins
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Ligands
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Proteins
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RETNLB protein, human
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Resistin
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Retn protein, mouse
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Retnla protein, mouse
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Thiazolidinediones
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Nerve Growth Factor
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2,4-thiazolidinedione
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Glucose