Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

Jeongsoo Yoo; David E Reichert; Michael J Welch

Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

Chem Commun (Camb). 2003 Mar 21:(6):766-7.

Authors

Jeongsoo Yoo¹, David E Reichert, Michael J Welch

Affiliation

¹ Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA.

PMID: 12703813

Abstract

All possible configurations of two different groups on the four nitrogen atoms of cyclen were achieved using four differently protected cyclen intermediates including the novel mono-protected cyclen compound, mono-N-Cbz-cyclen.