Abstract
In murine Lyme borreliosis, the absence of gamma delta T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gamma delta T cells are present, suggesting that vector effects can negate gamma delta T-cell functions in vivo.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Bacterial / blood*
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Borrelia burgdorferi / immunology*
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Enzyme-Linked Immunosorbent Assay
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Immunoglobulin G / blood
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Immunoglobulin G / classification
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Mice
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Mice, Inbred BALB C
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Receptors, Antigen, T-Cell, gamma-delta / physiology*
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T-Lymphocytes, Helper-Inducer / immunology*
Substances
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Antibodies, Bacterial
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Immunoglobulin G
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Receptors, Antigen, T-Cell, gamma-delta