Acceleration and augmentation strategies for treating bipolar depression

Biol Psychiatry. 2003 Apr 15;53(8):691-700. doi: 10.1016/s0006-3223(03)00087-8.

Abstract

Despite the prevalence and morbidity of bipolar depression, few randomized treatment trials have been conducted to assess clinical efficacy. Even fewer studies have assessed approaches that optimize treatment response for bipolar depression. This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Antidepressive Agents / therapeutic use
  • Antimanic Agents / therapeutic use
  • Antipsychotic Agents / therapeutic use
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / psychology
  • Bipolar Disorder / therapy*
  • Combined Modality Therapy
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology
  • Depressive Disorder / therapy*
  • Humans
  • Lithium / therapeutic use
  • Pindolol / therapeutic use
  • Randomized Controlled Trials as Topic
  • Sleep Deprivation
  • Thyroid Hormones / physiology

Substances

  • Adrenergic beta-Antagonists
  • Antidepressive Agents
  • Antimanic Agents
  • Antipsychotic Agents
  • Thyroid Hormones
  • Lithium
  • Pindolol