Abstract
Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment. We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously. To our knowledge, this is the first case of methotrexate-related acute cerebellar syndrome.
MeSH terms
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Acute Disease
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Adult
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / adverse effects*
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Cerebellar Diseases / chemically induced*
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Critical Care
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Female
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Humans
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Injections, Spinal
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Methotrexate / administration & dosage
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Methotrexate / adverse effects*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Treatment Outcome
Substances
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Antimetabolites, Antineoplastic
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Methotrexate