Abstract
Phytochemical investigation of the methanol extract of Euchresta formosana resulted in the isolation of thirty-four compounds. Compounds 1, 3-12, 15, 27, 29 and 32-24 were isolated from this species for the first time. These compounds were identified by spectral analyses and tested for antiplatelet aggregation and anti-HIV activities. Among these compounds, tectorigenin (1), 3',4',5-trihydroxyisoflavone (3), and euchretin F (19) were the most effective antiplatelet aggregation compounds; they inhibited both AA- (arachidonic acid) and collagen-induced platelet aggregation. Meanwhile, flemiphyllin (B), quercetin (13), euchretin M (23), and formosanatin C (26) inhibited HIV replication in H9 lymphocyte cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Arachidonic Acid
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Collagen
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Dose-Response Relationship, Drug
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Fabaceae*
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Flavonoids / administration & dosage
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Flavonoids / therapeutic use
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HIV-1 / drug effects
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Humans
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Inhibitory Concentration 50
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Lymphocytes / drug effects
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Roots
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / administration & dosage
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology*
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Platelet Aggregation Inhibitors / therapeutic use
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Rabbits
Substances
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Anti-HIV Agents
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Flavonoids
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Plant Extracts
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Platelet Aggregation Inhibitors
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Arachidonic Acid
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Collagen