Synthesis and biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one, 7-hydroxy-4,5-dimethyl-2H-chromen-2-one and their some derivatives

Khalid Mohammed Khan; Zafar S Saify; Saeedan Begum; Fatima Noor; Muhammad Zarrar Khan; Safdar Hayat; M Iqbal Choudhary; Shahnaz Perveen; Atta-Ur-Rahman; Zia-Ullah

doi:10.1080/1478641031000103704

Synthesis and biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one, 7-hydroxy-4,5-dimethyl-2H-chromen-2-one and their some derivatives

Nat Prod Res. 2003 Apr;17(2):115-25. doi: 10.1080/1478641031000103704.

Authors

Khalid Mohammed Khan¹, Zafar S Saify, Saeedan Begum, Fatima Noor, Muhammad Zarrar Khan, Safdar Hayat, M Iqbal Choudhary, Shahnaz Perveen, Atta-Ur-Rahman, Zia-Ullah

Affiliation

¹ HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. [email protected]

PMID: 12713124
DOI: 10.1080/1478641031000103704

Abstract

7-Hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9, 10 and 13 showed high degree of bactericidal activity amongst the present series.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Artemia / drug effects
Benzopyrans / administration & dosage
Benzopyrans / chemical synthesis
Benzopyrans / pharmacology*
Benzopyrans / therapeutic use
Gram-Negative Bacteria / drug effects*
Gram-Positive Bacteria / drug effects*
Humans
Lethal Dose 50
Microbial Sensitivity Tests
Phytotherapy*

Substances

Anti-Bacterial Agents
Benzopyrans