Abstract
A new sterol, ajugasalicigenin (1), and three new sterol glycosides, ajugasaliciosides F-H (2-4), were isolated and characterized from the aerial parts of Ajuga salicifolia. Compounds 1-4 are further representatives of the stigmastane type of sterols. Their cytotoxicity against KB (HeLa) and Jurkat T cancer cells was evaluated.
MeSH terms
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Ajuga / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Jurkat Cells / drug effects
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KB Cells / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Stereoisomerism
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Sterols / chemistry
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Sterols / isolation & purification*
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Sterols / pharmacology
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Tumor Cells, Cultured / drug effects
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Turkey
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Sterols
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ajugasalicigenin