Chemiluminescence detection in HPLC and CE for pharmaceutical and biomedical analysis

Biomed Chromatogr. 2003 Mar-Apr;17(2-3):96-105. doi: 10.1002/bmc.238.

Abstract

The present paper reviews the developments and applications of chemiluminescence detection with HPLC and CE in pharmaceutical and biomedical analysis. The chemiluminescence systems, chemiluminogenic reagents and derivatization reagents, improvements in instrumental design as well as their contributions to the practical applications, are all presented. The advantages and limitations of current detection methodology and future prospects for improvement are briefly discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomedical Technology*
  • Chromatography, High Pressure Liquid / methods*
  • Electrophoresis, Capillary / methods*
  • Luminescent Measurements
  • Manganese Compounds / analysis
  • Organometallic Compounds / analysis
  • Oxalates / analysis
  • Oxides / analysis
  • Pharmaceutical Preparations / chemistry*

Substances

  • Manganese Compounds
  • Organometallic Compounds
  • Oxalates
  • Oxides
  • Pharmaceutical Preparations
  • tris(2,2'-bipyridyl)ruthenium(II)
  • permanganic acid
  • peroxyoxalate