Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"?

Mol Cell. 2003 Apr;11(4):850-1. doi: 10.1016/s1097-2765(03)00133-3.

Abstract

Farnesoid X receptor (FXR) is a bile acid sensor that regulates lipid homeostasis. New structural data suggest that, unlike other nuclear receptors, FXR contains a second coactivator binding site and binds bile acids with the steroid backbone flipped head to tail, both of which have important functional ramifications.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Bile Acids and Salts / metabolism*
  • Binding Sites / drug effects
  • Binding Sites / physiology
  • DNA-Binding Proteins / drug effects
  • DNA-Binding Proteins / metabolism*
  • Eukaryotic Cells / metabolism*
  • Humans
  • Ligands
  • Protein Structure, Secondary / physiology
  • Receptors, Cytoplasmic and Nuclear / drug effects
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Transcription Factors / drug effects
  • Transcription Factors / metabolism*

Substances

  • Bile Acids and Salts
  • DNA-Binding Proteins
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • farnesoid X-activated receptor