Targeted gene disruption of the neuronal calcium sensor 1 homologue in rice blast fungus, Magnaporthe grisea

Biosci Biotechnol Biochem. 2003 Mar;67(3):651-3. doi: 10.1271/bbb.67.651.

Abstract

We isolated a neuronal calcium sensor 1/frequenin-like gene, Mg-NCS-1, from Magnaporthe grisea and evaluated the phenotypes of null-mutants of the gene. The putative Mg-NCS-1 protein showed high similarity to the other NCS-1 proteins. The null-mutants had normal growth and pathogenicity similar to the parental strain, but their growth was suppressed in high concentrations of Ca2+ or acidic conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Calcium / chemistry
  • Calcium / pharmacology
  • Calcium Signaling
  • Calcium-Binding Proteins / genetics*
  • Fungal Proteins / genetics
  • Hydrogen-Ion Concentration
  • Magnaporthe / genetics*
  • Magnaporthe / growth & development
  • Magnaporthe / pathogenicity
  • Molecular Sequence Data
  • Mutation
  • Nerve Tissue Proteins / genetics
  • Neuronal Calcium-Sensor Proteins
  • Neuropeptides / genetics*
  • Phenotype
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transformation, Genetic

Substances

  • Calcium-Binding Proteins
  • Fungal Proteins
  • Nerve Tissue Proteins
  • Neuronal Calcium-Sensor Proteins
  • Neuropeptides
  • frequenin calcium sensor proteins
  • Calcium

Associated data

  • GENBANK/AB083403