Abstract
The essential oil of Lippia multiflora Moldenke (Verbenaceae) produced by conventional hydrodistillation was analyzed and studied for its analgesic, antipyretic and anti-inflammatory activities in rats and mice. At the doses used (2, 4 and 8 ml/kg o.s.) the essential oil of L. multiflora showed significant and dose-dependent analgesic effect on acetic acid-induced writhing in mice. Only the dose of 8 ml/kg of essential oil, antagonized hyperexia induced by brewer's yeast. No effect on granuloma formation was observed.
MeSH terms
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Acetic Acid
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Administration, Oral
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Analgesics / administration & dosage
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Analgesics / pharmacology*
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Analgesics / therapeutic use
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Analgesics, Non-Narcotic / administration & dosage
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Analgesics, Non-Narcotic / pharmacology*
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Analgesics, Non-Narcotic / therapeutic use
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Animals
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Dose-Response Relationship, Drug
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Fever / prevention & control*
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Granuloma, Foreign-Body / prevention & control
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Lippia*
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Male
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Mice
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Pain / chemically induced
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Pain / prevention & control*
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Pain Measurement / drug effects*
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Phytotherapy*
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Plant Leaves
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Plant Oils / administration & dosage
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Plant Oils / pharmacology*
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Plant Oils / therapeutic use
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Rats
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Rats, Wistar
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Saccharomyces cerevisiae
Substances
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Analgesics
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Analgesics, Non-Narcotic
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Plant Oils
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Acetic Acid