Abstract
A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and in vivo. The synthesis and biological activity of these compounds are discussed.
MeSH terms
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Administration, Oral
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Animals
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Biological Availability
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Dogs
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Growth Hormone / analysis
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Growth Hormone / metabolism*
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Piperidines / chemical synthesis*
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Piperidines / pharmacokinetics*
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Piperidines / pharmacology
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Pituitary Gland / cytology
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Rats
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Structure-Activity Relationship
Substances
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Piperidines
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Growth Hormone