Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole

Eric Nulens; Cathrien Eggink; Antonius J M M Rijs; Pieter Wesseling; Paul E Verweij

doi:10.1128/JCM.41.5.2261-2264.2003

Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole

J Clin Microbiol. 2003 May;41(5):2261-4. doi: 10.1128/JCM.41.5.2261-2264.2003.

Authors

Eric Nulens¹, Cathrien Eggink, Antonius J M M Rijs, Pieter Wesseling, Paul E Verweij

Affiliation

¹ Department of Medical Microbiology, University Medical Center Nijmegen and Nijmegen University Center for Infectious Diseases, The Netherlands. [email protected]

Abstract

A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.

Publication types

Case Reports

MeSH terms

Antifungal Agents / therapeutic use*
Ascomycota / drug effects
Ascomycota / isolation & purification
Ascomycota / pathogenicity*
Corneal Transplantation
Corneal Ulcer / drug therapy*
Corneal Ulcer / microbiology*
Corneal Ulcer / surgery
Humans
Keratoplasty, Penetrating
Male
Middle Aged
Pyrimidines / therapeutic use*
Triazoles / therapeutic use*
Voriconazole

Substances

Antifungal Agents
Pyrimidines
Triazoles
Voriconazole