Diversity of the biosynthesis of the isoprene units

Nat Prod Rep. 2003 Apr;20(2):171-83. doi: 10.1039/b109860h.

Abstract

This review covers the biosynthesis of the starter units of terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase. The biosynthesis of terpenoids produced by actinomycetes is also reviewed. 117 references are cited.

Publication types

  • Review

MeSH terms

  • Actinomyces / metabolism*
  • Butadienes / chemistry
  • Butadienes / metabolism*
  • Carbon-Carbon Double Bond Isomerases / metabolism*
  • Hemiterpenes*
  • Mevalonic Acid / chemistry
  • Mevalonic Acid / metabolism
  • Organophosphorus Compounds / chemistry
  • Organophosphorus Compounds / metabolism*
  • Pentanes*
  • Terpenes / chemistry
  • Terpenes / metabolism*

Substances

  • Butadienes
  • Hemiterpenes
  • Organophosphorus Compounds
  • Pentanes
  • Terpenes
  • isoprene
  • isopentenyl pyrophosphate
  • Carbon-Carbon Double Bond Isomerases
  • isopentenyldiphosphate delta-isomerase
  • Mevalonic Acid