Abstract
We have synthesized and characterized some oxidative metabolites of S-2474. In this study, we discovered a novel skeleton, the 2,3-dihydrobenzofuran derivative, which inhibited PGE(2) production at a very low concentration and was effective in the anti-carrageenin footpad edema assay.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / metabolism
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Anti-Inflammatory Agents / pharmacology
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Benzofurans / chemical synthesis*
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Benzofurans / pharmacology
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Cyclic S-Oxides / chemistry*
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Cyclic S-Oxides / metabolism
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Cyclic S-Oxides / pharmacology
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Dinoprostone / antagonists & inhibitors
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Dinoprostone / biosynthesis
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Edema / drug therapy
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Edema / metabolism
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Humans
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Interleukin-1 / metabolism
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Leukotriene B4 / metabolism
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Lipoxygenase Inhibitors*
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Microsomes, Liver / metabolism
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Rats
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Thiazoles / chemistry*
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Thiazoles / metabolism
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Thiazoles / pharmacology
Substances
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((E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)- 2-ethyl-1,2-isothiazolidine-1,1-dioxide)
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Anti-Inflammatory Agents
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Benzofurans
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Cyclic S-Oxides
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Interleukin-1
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Lipoxygenase Inhibitors
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Thiazoles
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Leukotriene B4
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Dinoprostone