[Allergy investigations after two cases of adverse reactions to a neuromuscular blocking agent and management for subsequent general anaesthesia]

N Louvier; A Chomel; E Collet; A Juniot; M Pillet

doi:10.1016/s0750-7658(02)00802-x

[Allergy investigations after two cases of adverse reactions to a neuromuscular blocking agent and management for subsequent general anaesthesia]

Ann Fr Anesth Reanim. 2003 Jan;22(1):54-7. doi: 10.1016/s0750-7658(02)00802-x.

[Article in French]

Authors

N Louvier¹, A Chomel, E Collet, A Juniot, M Pillet

Affiliation

¹ Département d'anesthésie-réanimation, CHU Dijon, hôpital général, 21000 Dijon, France. [email protected]

PMID: 12738022
DOI: 10.1016/s0750-7658(02)00802-x

Abstract

We report two cases of severe anaphylactic reactions to rocuronium. Diagnosis was confirmed by skin tests and specific IgE assay. Cross-reactivity to all neuromuscular blocking agents was investigated by intradermal tests and leucocyte histamine release test. Intradermal tests and leukocyte histamine release were negative for cisatracurium. The two patients had undergone a subsequent general anaesthesia using cisatracurium and did not present any adverse reaction.

Publication types

Case Reports

MeSH terms

Aged
Anaphylaxis / physiopathology
Androstanols / adverse effects*
Androstanols / immunology
Anesthesia, General*
Atracurium / immunology
Cross Reactions
Drug Hypersensitivity / diagnosis*
Drug Hypersensitivity / therapy*
Histamine Release / drug effects
Humans
Immunoglobulin E / analysis
Leukocytes / drug effects
Leukocytes / metabolism
Male
Middle Aged
Neuromuscular Nondepolarizing Agents / adverse effects*
Neuromuscular Nondepolarizing Agents / immunology
Rocuronium
Skin Tests

Substances

Androstanols
Neuromuscular Nondepolarizing Agents
Atracurium
Immunoglobulin E
Rocuronium