Abstract
Immunoglobulin D (IgD) multiple myeloma is rare, accounting for less than 2% of all patients with multiple myeloma. The main presenting features are bone pain in 70% of patients. Extramedullary involvement is less common. We report a case of Ig D lambda multiple myeloma in a 74-year-old man that was revealed by pleural effusion and dyspnea. This effusion was found to be caused by multiple myeloma after electrophoretic and cytologic assays. The patient received a course of chemotherapy with melphalan and prednisone. The patient died one month later with signs of septic shock. Pleural effusion as a first sign of Ig D multiple myeloma is rarely described and the prognosis associated with such a localisation is very poor.
Publication types
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Case Reports
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Comparative Study
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English Abstract
MeSH terms
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Aged
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / therapeutic use
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Antineoplastic Agents, Alkylating / administration & dosage
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Antineoplastic Agents, Alkylating / therapeutic use
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Drug Therapy, Combination
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Dyspnea / etiology
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Humans
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Immunoelectrophoresis
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Immunoglobulin D / analysis*
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Immunoglobulin lambda-Chains / analysis*
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Male
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Melphalan / administration & dosage
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Melphalan / therapeutic use
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Multiple Myeloma / diagnosis*
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Multiple Myeloma / drug therapy
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Multiple Myeloma / immunology
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Pleural Effusion / etiology*
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Prednisone / administration & dosage
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Prednisone / therapeutic use
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Time Factors
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents, Alkylating
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Immunoglobulin D
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Immunoglobulin lambda-Chains
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Melphalan
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Prednisone