Abstract
Intrathecal clonidine was tested for the control of bladder hyperreflexia resistant to pararsympathicolytic drugs in spinal cord injured patients. Urodynamic parameters were significantly improved after acute bolus of intrathecal low doses of clonidine. Unfortunately, the chronic intrathecal infusion of clonidine induced cardiovascular side-effects. Intrathecal baclofen did not modified significantly neurogenic bladder dysfunction from spinal lesion. But intrathecal baclofen modified penile erection quality and impaired the ejaculation reflex induced by penile vibratory stimulation in the same population.
MeSH terms
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Adrenergic alpha-Agonists / administration & dosage
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Adrenergic alpha-Agonists / adverse effects
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Adrenergic alpha-Agonists / therapeutic use*
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Baclofen / administration & dosage
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Baclofen / adverse effects
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Baclofen / therapeutic use
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Clonidine / administration & dosage
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Clonidine / adverse effects
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Clonidine / therapeutic use*
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Female
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Humans
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Injections, Spinal
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Male
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Muscle Relaxants, Central / administration & dosage
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Muscle Relaxants, Central / adverse effects
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Muscle Relaxants, Central / therapeutic use
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Sexual Dysfunction, Physiological / chemically induced
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Spinal Cord Injuries / complications*
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Urinary Bladder, Neurogenic / drug therapy*
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Urinary Bladder, Neurogenic / etiology
Substances
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Adrenergic alpha-Agonists
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Muscle Relaxants, Central
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Baclofen
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Clonidine