Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells

Phytother Res. 2003 May;17(5):563-5. doi: 10.1002/ptr.1166.

Abstract

Two hepatoprotective phenolic compounds, kaempferol (2) and salidroside (4), were isolated from the roots of Rhodiola sachalinensis together with two inactive compounds cinnamyl alcohol (1) and daucosterol (3) based on the hepatoprotective activity against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 2 and 4 were 33.5 and 51.3 micro m, respectively. Silybin as a positive control showed an EC(50) value of 68.4 micro m.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Division / drug effects
  • Dose-Response Relationship, Drug
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Glucosides / chemistry
  • Glucosides / pharmacology*
  • Humans
  • Kaempferols*
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / pharmacology*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Rhodiola*
  • Tacrine / pharmacology
  • Tumor Cells, Cultured / drug effects

Substances

  • Flavonoids
  • Glucosides
  • Kaempferols
  • Phenols
  • Plant Extracts
  • Tacrine
  • kaempferol
  • rhodioloside