Abstract
1,2,3,5-tetra-O-acetyl-4-thio-beta-L-ribofuranose (13) was synthesized by an improved five-step sequence starting from methyl alpha-D-lyxopyranoside. Compound 13 was then converted to the corresponding L-4'-thionucleosides 4-6 and 19 by a modified Vorbrüggen procedure. All of these nucleoside analogues were tested for their antitumour activity in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Cell Line
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Cell Line, Tumor
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Humans
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Inhibitory Concentration 50
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Rats
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Ribonucleosides / chemical synthesis*
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Ribonucleosides / chemistry
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Ribonucleosides / pharmacology*
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Thionucleosides / chemical synthesis*
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Thionucleosides / chemistry
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Thionucleosides / pharmacology*
Substances
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Antineoplastic Agents
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Ribonucleosides
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Thionucleosides