Abstract
In this issue of Cell, G. Pavlath and coworkers demonstrate a novel role for Interleukin-4 (IL-4) in regulating the fusion of myoblasts with differentiated myotubes. The authors demonstrate that NFATc2 signaling in newly formed myotubes induces IL-4 expression and secretion which promotes myoblast fusion with pre-existing myotubes.
MeSH terms
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Animals
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Cell Differentiation / physiology*
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Cell Fusion
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Humans
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Hypertrophy / metabolism
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Interleukin-4 / metabolism*
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Muscle Fibers, Skeletal / cytology
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Muscle Fibers, Skeletal / metabolism*
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Muscle, Skeletal / cytology
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Muscle, Skeletal / growth & development*
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Muscle, Skeletal / metabolism
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Myoblasts, Skeletal / cytology
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Myoblasts, Skeletal / metabolism*
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Signal Transduction / physiology