The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates

Florence Hommais; Stéphanie Gouriou; Christine Amorin; Hung Bui; Mohamed Chérif Rahimy; Bertrand Picard; Erick Denamur

doi:10.1128/IAI.71.6.3619-3622.2003

The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates

Infect Immun. 2003 Jun;71(6):3619-22. doi: 10.1128/IAI.71.6.3619-3622.2003.

Authors

Florence Hommais¹, Stéphanie Gouriou, Christine Amorin, Hung Bui, Mohamed Chérif Rahimy, Bertrand Picard, Erick Denamur

Affiliation

¹ INSERM U458, Hôpital Robert Debré Centre d'Etude du Polymorphisme Humain, Hôpital Saint Louis, Paris, France.

Abstract

Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adhesins, Escherichia coli / genetics*
Adhesins, Escherichia coli / physiology
Escherichia coli / classification
Escherichia coli / pathogenicity*
Fimbriae Proteins / genetics*
Fimbriae Proteins / physiology
Humans
Mutation*
Phylogeny
Urinary Tract Infections / microbiology*
Virulence

Substances

Adhesins, Escherichia coli
fimH protein, E coli
Fimbriae Proteins