Callyspongenols A-C, new cytotoxic C22-polyacetylenic alcohols from a red sea sponge, Callyspongia species

J Nat Prod. 2003 May;66(5):679-81. doi: 10.1021/np030006c.

Abstract

Investigation of the organic extract of a Red Sea sponge, Callyspongia sp., resulted in isolation and identification of three new C(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies and mass spectral determinations. Compounds 1-4 showed moderate cytotoxicity against P388 and HeLa cells.

MeSH terms

  • Acetylene / analogs & derivatives*
  • Acetylene / chemistry
  • Acetylene / isolation & purification*
  • Acetylene / pharmacology
  • Alcohols / chemistry
  • Alcohols / isolation & purification*
  • Alcohols / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Doxorubicin / pharmacology
  • Drug Screening Assays, Antitumor
  • HeLa Cells / drug effects
  • Humans
  • Indian Ocean
  • Inhibitory Concentration 50
  • Leukemia P388
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Polymers / chemistry
  • Polymers / isolation & purification*
  • Polymers / pharmacology
  • Polyynes
  • Porifera / chemistry*
  • Tumor Cells, Cultured / drug effects

Substances

  • Alcohols
  • Antineoplastic Agents
  • Polymers
  • callyspongenol A
  • callyspongenol B
  • callyspongenol C
  • Polyynes
  • Doxorubicin
  • Acetylene