Abstract
In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH-EtOAc (1:1) extract of the sponge Plakortis aff simplex, collected in Madagascar, was found to be cytotoxic to a series of human tumor cells. From this sponge, three new compounds and one known one, two new 1,2-dioxane peroxylactones named plakortolides H (1) and I (2), and one new 1,2-dioxolane, designated andavadoic acid (3), have been isolated and their structures elucidated. In addition, the known N(3)-methyladenine (4) was isolated, to the best of our knowledge, for the first time from a marine source. Andavadoic acid (3) showed significant activity against 13 tumor cells with GI(50) values in the submicromolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds, 1-Ring / chemistry
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Heterocyclic Compounds, 1-Ring / isolation & purification*
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Heterocyclic Compounds, 1-Ring / pharmacology
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Heterocyclic Compounds, 2-Ring / chemistry
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Heterocyclic Compounds, 2-Ring / isolation & purification*
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Heterocyclic Compounds, 2-Ring / pharmacology
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Humans
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Inhibitory Concentration 50
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Madagascar
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Peroxides / chemistry
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Peroxides / isolation & purification*
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Peroxides / pharmacology
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Porifera / chemistry*
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, 1-Ring
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Heterocyclic Compounds, 2-Ring
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Peroxides
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andavadoic acid
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plakortolide H
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plakortolide I