FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications

Gilles Crambert; Pascal Béguin; Marc Uldry; Florianne Monnet-Tschudi; Jean-Daniel Horisberger; Haim Garty; Käthi Geering

doi:10.1111/j.1749-6632.2003.tb07227.x

FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications

Ann N Y Acad Sci. 2003 Apr:986:444-8. doi: 10.1111/j.1749-6632.2003.tb07227.x.

Authors

Gilles Crambert¹, Pascal Béguin, Marc Uldry, Florianne Monnet-Tschudi, Jean-Daniel Horisberger, Haim Garty, Käthi Geering

Affiliation

¹ Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland.

PMID: 12763863
DOI: 10.1111/j.1749-6632.2003.tb07227.x

Abstract

The FXYD protein family has recently been defined as a result of the search for homologues of the Na,K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. FXYD7 has been seen to have a role as a brain- and isozyme-specific regulator of Na/K-ATPase. In this study, the biosynthesis, membrane topology, nature, and role of the processing of FXYD7 are investigated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism
Kinetics
Membrane Glycoproteins / metabolism*
Nerve Tissue Proteins / metabolism*
Protein Isoforms / metabolism
Protein Processing, Post-Translational*
Sodium-Potassium-Exchanging ATPase / biosynthesis*

Substances

Fxyd7 protein, mouse
Membrane Glycoproteins
Nerve Tissue Proteins
Protein Isoforms
Sodium-Potassium-Exchanging ATPase