Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties

Eur J Med Chem. 2003 May;38(5):513-8. doi: 10.1016/s0223-5234(03)00074-6.

Abstract

A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.

Publication types

  • Comparative Study

MeSH terms

  • Acetic Acid / antagonists & inhibitors
  • Acetic Acid / toxicity
  • Administration, Oral
  • Amides / chemistry
  • Amides / pharmacology*
  • Amides / toxicity*
  • Analgesics, Non-Narcotic / chemistry*
  • Analgesics, Non-Narcotic / toxicity*
  • Animals
  • Ibuprofen / analogs & derivatives*
  • Ibuprofen / pharmacology
  • Ibuprofen / toxicity
  • Injections, Intraperitoneal
  • Magnetic Resonance Spectroscopy
  • Male
  • Pain / chemically induced
  • Pain Measurement / drug effects
  • Pain Measurement / methods
  • Pyridinium Compounds / chemistry
  • Pyridinium Compounds / pharmacology*
  • Pyridinium Compounds / toxicity*
  • Rats
  • Rats, Sprague-Dawley
  • Spectrophotometry, Infrared
  • Stomach Ulcer / prevention & control
  • Structure-Activity Relationship

Substances

  • Amides
  • Analgesics, Non-Narcotic
  • Pyridinium Compounds
  • Acetic Acid
  • Ibuprofen