Abstract
Signal transduction pathways are frequently altered in human breast cancer and are the targets of several novel therapies currently in clinical trials. Therapeutic strategies include extracellular blockade of tyrosine kinase receptors with the monoclonal antibodies C225 and trastuzumab. Competitive inhibitors of adenosine triphosphate binding sites on tyrosine and serine/threonine kinases are also being evaluated in phase I/II trials; these include ZD1839, OSI-774 and CI-1033. Flavopiridol and UCN-01 are nonspecific cell cycle kinase antagonists with preliminary evidence of breast cancer cell growth inhibition. Several inhibitors of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling are also in various stages of preclinical or clinical development. Additionally, inhibitors of farnesyl transferase have demonstrated activity in breast cancer cells irrespective of ras status. Current evidence suggests that targeting of signaling molecules is a promising new approach to treatment of breast cancer.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors
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Alkyl and Aryl Transferases / biosynthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / enzymology
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Breast Neoplasms / metabolism
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Cell Cycle / drug effects
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Clinical Trials, Phase I as Topic
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Clinical Trials, Phase II as Topic
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Farnesyltranstransferase
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Female
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Humans
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Mitogen-Activated Protein Kinases / antagonists & inhibitors
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Mitogen-Activated Protein Kinases / biosynthesis
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Phosphatidylinositol 3-Kinases / biosynthesis
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Phosphoinositide-3 Kinase Inhibitors
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
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Receptor Protein-Tyrosine Kinases / biosynthesis
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Signal Transduction / drug effects*
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Treatment Outcome
Substances
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Antineoplastic Agents
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Phosphoinositide-3 Kinase Inhibitors
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Alkyl and Aryl Transferases
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Farnesyltranstransferase
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Receptor Protein-Tyrosine Kinases
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Mitogen-Activated Protein Kinases