Abstract
From the root bark of Millettia pervilleana, which had shown significant cytotoxic activity, a 3-phenylcoumarin, named pervilleanine, two new pterocarpans, pervilline and pervillinine, and one known, emoroidocarpan, were isolated in addition to rotenone and 3alpha-hydroxyrotenone. The anticancer activity of two previously isolated isoflavanones, pervilleanone and 3'-O-demethylpervilleanone is reported.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification
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Drug Screening Assays, Antitumor
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Humans
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Isoflavones / chemistry
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Isoflavones / isolation & purification*
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Isoflavones / pharmacology
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Millettia / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plant Roots / chemistry
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Plants, Medicinal / chemistry
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Pterocarpans / chemistry
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Pterocarpans / isolation & purification
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Rotenone / chemistry
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Rotenone / isolation & purification
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Rotenone / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Coumarins
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Isoflavones
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Pterocarpans
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Rotenone