The present view of the mechanism of protein folding

Nat Rev Mol Cell Biol. 2003 Jun;4(6):497-502. doi: 10.1038/nrm1126.

Abstract

We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Proteins
  • Models, Molecular
  • Peptides / chemistry
  • Plant Proteins
  • Protein Conformation
  • Protein Folding*
  • Proteins / chemistry
  • Ribonucleases / chemistry
  • Temperature
  • Thermodynamics

Substances

  • Bacterial Proteins
  • Peptides
  • Plant Proteins
  • Proteins
  • chymotrypsin inhibitor 2
  • Ribonucleases
  • Bacillus amyloliquefaciens ribonuclease