Abstract
Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antibody Specificity*
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Breast Neoplasms / immunology*
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Breast Neoplasms / therapy
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CD8-Positive T-Lymphocytes / immunology*
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Cell Line, Transformed
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Cytotoxicity, Immunologic / immunology*
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Dendritic Cells / immunology*
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Humans
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Immunotherapy, Adoptive*
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Lymphocytes, Tumor-Infiltrating / immunology
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Mammaglobin A
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Neoplasm Proteins / immunology*
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Tumor Cells, Cultured
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Uteroglobin / immunology*
Substances
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Mammaglobin A
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Neoplasm Proteins
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SCGB2A2 protein, human
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Uteroglobin