Transgenics at breaking-point

Cancer Cell. 2003 May;3(5):411-3. doi: 10.1016/s1535-6108(03)00112-0.

Abstract

In this issue of Cancer Cell, Forster et al. (2003) have generated mice that recapitulate both the mechanism (sporadic somatic translocation) and the consequences (expression of two translocation fusion genes) leading to an accurate leukemia model.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA, Complementary / metabolism
  • Disease Models, Animal*
  • Humans
  • Integrases
  • Leukemia / genetics*
  • Mice
  • Mice, Transgenic*
  • Models, Genetic
  • Translocation, Genetic*
  • Viral Proteins

Substances

  • DNA, Complementary
  • Viral Proteins
  • Cre recombinase
  • Integrases