Electron attachment to uracil: effective destruction at subexcitation energies

Phys Rev Lett. 2003 May 9;90(18):188104. doi: 10.1103/PhysRevLett.90.188104. Epub 2003 May 8.

Abstract

We demonstrate that electrons at energies below the threshold for electronic excitation (<3 eV) effectively decompose gas phase uracil generating a mobile hydrogen radical and the corresponding closed shell uracil fragment anion (U-H)(-). The reaction is energetically driven by the large electron affinity of the (U-H) radical. This observation has significant consequences for the molecular picture of radiation damage, i.e., genotoxic effects or damage of living cells due to the secondary component of high energy radiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Damage
  • Electrons*
  • RNA / chemistry
  • RNA / radiation effects
  • Uracil / chemistry*

Substances

  • Uracil
  • RNA