Nanog: a new recruit to the embryonic stem cell orchestra

Cell. 2003 May 30;113(5):551-2. doi: 10.1016/s0092-8674(03)00394-5.

Abstract

In this issue of Cell, and add a new transcriptional operating system to the known Oct4 and Stat3 systems required for early embryonal stem cell potency and self-renewal. Nanog, a homeobox transcription factor, plays a crucial role in the second embryonic cell fate specification following formation of the blastocyst.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • Cell Lineage / genetics
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Embryo, Mammalian / embryology
  • Embryo, Mammalian / metabolism*
  • Gene Expression Regulation, Developmental / genetics
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / isolation & purification
  • Mice
  • Octamer Transcription Factor-3
  • STAT3 Transcription Factor
  • Totipotent Stem Cells / metabolism*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / isolation & purification

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Octamer Transcription Factor-3
  • Pou5f1 protein, mouse
  • STAT3 Transcription Factor
  • Stat3 protein, mouse
  • Trans-Activators
  • Transcription Factors