Abstract
Inducible nitric oxide synthase (iNOS) has important functions in innate immunity and regulation of immune functions. Here, the role of iNOS in the pathogenesis of various intracellular bacterial infections is discussed. These pathogens have also evolved a broad array of strategies to repair damage by reactive nitrogen intermediates, and to suppress or inhibit functions of iNOS.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Bacteria / drug effects
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Bacteria / enzymology
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Bacteria / pathogenicity
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Bacterial Infections / metabolism
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Bacterial Infections / microbiology*
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Immunity, Innate
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Mice
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Mice, Knockout
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Models, Immunological
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Nitric Oxide / metabolism
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Nitric Oxide / pharmacology
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Nitric Oxide Synthase / physiology*
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Nitric Oxide Synthase Type II
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Reactive Oxygen Species / metabolism
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Reactive Oxygen Species / pharmacology
Substances
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Anti-Bacterial Agents
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Reactive Oxygen Species
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Nitric Oxide
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse