Sexual recombination and clonal evolution of virulence in Toxoplasma

Microbes Infect. 2003 Jun;5(7):685-90. doi: 10.1016/s1286-4579(03)00088-1.

Abstract

The protozoan parasite Toxoplasma gondii is endemic worldwide. For such a widespread pathogen that has few geographic or host boundaries, it possess an unexpected population structure comprised principally of three clonally propagated lineages. The origin and the evolutionary dynamics of these three lines are unclear. Recent population genetic analyses suggest that a meiotic recombination between two discrete gene pools produces a pandemic outbreak of three super-successful lines, which have recently come to dominate most other strains worldwide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Evolution, Molecular
  • Meiosis
  • Molecular Sequence Data
  • Recombination, Genetic
  • Sequence Alignment
  • Toxoplasma / genetics*
  • Toxoplasma / pathogenicity*
  • Virulence