Aid to the antemortem diagnosis of Fell pony foal syndrome by the analysis of B lymphocytes

G W Thomas; S C Bell; C Phythian; P Taylor; D C Knottenbelt; S D Carter

doi:10.1136/vr.152.20.618

Aid to the antemortem diagnosis of Fell pony foal syndrome by the analysis of B lymphocytes

Vet Rec. 2003 May 17;152(20):618-21. doi: 10.1136/vr.152.20.618.

Authors

G W Thomas¹, S C Bell, C Phythian, P Taylor, D C Knottenbelt, S D Carter

Affiliation

¹ Department of Veterinary Pathology, University of Liverpool, Liverpool L69 7ZJ.

PMID: 12790165
DOI: 10.1136/vr.152.20.618

Abstract

Fell pony foals are affected by a congenital fatal immunodeficiency that commonly leads to anaemia and lymphopenia. Previous work has shown that the foals' circulating subpopulations of CD4 and CD8 T lymphocytes are unaffected. In this study it was shown that the mean population of B lymphocytes in 10 affected foals was less than 10 per cent of that in normal foals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
B-Lymphocytes / cytology*
B-Lymphocytes / immunology
Flow Cytometry
Horse Diseases / blood
Horse Diseases / diagnosis*
Horse Diseases / immunology
Horses
Immunologic Deficiency Syndromes / blood
Immunologic Deficiency Syndromes / diagnosis*
Immunologic Deficiency Syndromes / immunology
Immunologic Deficiency Syndromes / veterinary*
Lymphocyte Count
Syndrome