Abstract
We investigated a possible relationship between apoptosis induction by fenretinide (4HPR) and the expression of a group of genes thought to be essential in morphogenesis and development, the DLX genes. We analyzed their expression under normal conditions or upon 4HPR stimulation in several tumor cell lines. We show that DLX2, DLX3 and DLX4 were expressed at higher levels in cell lines which where more sensitive to apoptotic induction, whereas DLX 5 and 6 appeared to segregate in a distinct functional compartment. Our data support the notion that DLX2, 3, 4 genes could participate in the control of 4HPR-mediated apoptosis, making them important molecules for the monitoring of therapy efficacy in cancer patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects*
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Cell Cycle / drug effects
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Cytoskeletal Proteins
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Fenretinide / pharmacology*
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Gene Expression Regulation, Neoplastic
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / metabolism
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Humans
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / pathology
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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RNA, Messenger / analysis
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RNA, Neoplasm / genetics
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RNA, Neoplasm / metabolism
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RNA-Binding Proteins
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Transcription Factors / genetics*
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Transcription Factors / metabolism
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Tumor Cells, Cultured
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bcl-X Protein
Substances
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Antineoplastic Agents
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BCL2L1 protein, human
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Cytoskeletal Proteins
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DLX4 protein, human
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DNA-Binding Proteins
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Distal-less homeobox proteins
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Homeodomain Proteins
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Proto-Oncogene Proteins c-bcl-2
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RNA, Messenger
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RNA, Neoplasm
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RNA-Binding Proteins
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Tes protein, mouse
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Transcription Factors
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bcl-X Protein
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Fenretinide