p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis

Breast Cancer Res. 2003;5(3):162-3. doi: 10.1186/bcr596. Epub 2003 Mar 31.

Author

Robert B Clarke¹

Affiliation

¹ Breast Biology Group, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK. [email protected]

PMID: 12793899
PMCID: PMC165008
DOI: 10.1186/bcr596

No abstract available

Publication types

Review

MeSH terms

Breast Neoplasms / chemistry
Breast Neoplasms / enzymology
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Cell Cycle Proteins / antagonists & inhibitors
Cell Cycle Proteins / metabolism*
Cell Cycle Proteins / physiology
Cyclin-Dependent Kinase Inhibitor p27
Humans
Phosphorylation
Prognosis
Protein Serine-Threonine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-akt
Tumor Suppressor Proteins / antagonists & inhibitors
Tumor Suppressor Proteins / metabolism*
Tumor Suppressor Proteins / physiology

Substances

Cell Cycle Proteins
Proto-Oncogene Proteins
Tumor Suppressor Proteins
Cyclin-Dependent Kinase Inhibitor p27
AKT1 protein, human
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt