Dysferlin mutations in Japanese Miyoshi myopathy: relationship to phenotype

Neurology. 2003 Jun 10;60(11):1799-804. doi: 10.1212/01.wnl.0000068333.43005.12.

Abstract

Objective: To study dysferlin gene mutations and genotype-phenotype correlations in Japanese patients with Miyoshi myopathy (MM).

Background: MM is an autosomal recessive distal muscular dystrophy that arises from mutations in the dysferlin gene. This gene is also mutated in families with limb girdle muscular dystrophy 2B.

Methods: The authors examined 25 Japanese patients with MM. Genomic DNA was extracted from the peripheral lymphocytes of the patients. The PCR products of each of 55 exons were screened by single strand conformation polymorphism or direct sequencing from the PCR fragments.

Results: The authors identified 16 different mutations in 20 patients with MM; 10 were novel. Mutations in Japanese patients are distributed along the entire length of the gene.

Conclusions: Four mutations (C1939G, G3370T, 3746delG, and 4870delT) are relatively more prevalent in this population, accounting for 60% of the mutations in this study. This study revealed that the G3370T mutation was associated with milder forms of MM and the G3510A mutation was associated with a more severe form.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Creatine Kinase / blood
  • DNA Mutational Analysis
  • Dysferlin
  • Female
  • Genotype
  • Humans
  • Japan / epidemiology
  • Male
  • Membrane Proteins*
  • Middle Aged
  • Muscle Proteins / genetics*
  • Muscular Dystrophies / diagnosis*
  • Muscular Dystrophies / epidemiology
  • Muscular Dystrophies / genetics*
  • Mutation*
  • Phenotype
  • Polymorphism, Genetic

Substances

  • DYSF protein, human
  • Dysferlin
  • Membrane Proteins
  • Muscle Proteins
  • Creatine Kinase