Abstract
Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.
MeSH terms
-
Alkylation
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / pharmacology
-
Antiviral Agents / chemical synthesis*
-
Antiviral Agents / pharmacology*
-
Benzimidazoles / chemistry
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Cytopathogenic Effect, Viral / drug effects
-
Drug Design
-
Humans
-
Indicators and Reagents
-
Ketones / chemical synthesis
-
Ketones / chemistry
-
Respiratory Syncytial Viruses / drug effects*
-
Structure-Activity Relationship
-
Triazoles / chemical synthesis*
-
Triazoles / pharmacology*
Substances
-
Antineoplastic Agents
-
Antiviral Agents
-
Benzimidazoles
-
Indicators and Reagents
-
Ketones
-
Triazoles
-
benzotriazole