Structure of the O-polysaccharide of Proteus vulgaris O44: a new O-antigen that contains an amide of D-glucuronic acid with L-alanine

Carbohydr Res. 2003 Jun 23;338(13):1431-5. doi: 10.1016/s0008-6215(03)00096-x.

Abstract

The O-polysaccharide of Proteus vulgaris O44, strain PrK 67/57 was studied by 1H and 13C NMR spectroscopy, including 2D COSY, TOCSY, ROESY, H-detected 1H, 13C HMQC, HMQC-TOCSY and HMBC experiments. The polysaccharide was found to contain an amide of D-glucuronic acid with L-alanine [D-GlcA6(L-Ala)], and the following structure of the linear pentasaccharide repeating unit was established: [structure: see text]. The structural data of the O-polysaccharide and the results of serological studies with P. vulgaris O44 O-antiserum showed that the strain studied is unique among Proteus bacteria, which is in agreement with its classification in a separate Proteus serogroup, O44.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylgalactosamine / analysis
  • Alanine / analysis
  • Amides / chemistry
  • Amino Sugars / analysis
  • Carbohydrate Sequence
  • Cross Reactions / immunology
  • Galactose / analysis
  • Glucose / analysis
  • Glucuronic Acid / analysis
  • Magnetic Resonance Spectroscopy
  • O Antigens / chemistry*
  • O Antigens / immunology
  • Proteus mirabilis / chemistry
  • Proteus mirabilis / immunology
  • Proteus vulgaris / chemistry*

Substances

  • 3-amino-3,6-dideoxygalactose
  • Amides
  • Amino Sugars
  • O Antigens
  • Glucuronic Acid
  • Glucose
  • Acetylgalactosamine
  • Alanine
  • Galactose