Abstract
Vancomycin-intermediate Staphylococcus aureus (VISA) are an emerging problem. We observed a statistically significant inverse relationship in the MICs of vancomycin and oxacillin in S. aureus isolates from a patient undergoing hemodialysis who received 26 weeks of treatment with vancomycin during November 1999 through April 2000. All isolates were mecA positive and were indistinguishable by pulsed-field gel electrophoresis. The evolving susceptibility patterns of this strain highlight the challenges of detecting and treating VISA infections.
MeSH terms
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Bacteremia / drug therapy*
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Bacterial Proteins*
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Biological Evolution
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Carrier Proteins / genetics
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Hexosyltransferases*
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Humans
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Male
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Methicillin / pharmacology
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Methicillin Resistance / genetics
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Microbial Sensitivity Tests
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Middle Aged
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Muramoylpentapeptide Carboxypeptidase / genetics
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Penicillin-Binding Proteins
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Peptidyl Transferases*
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / physiology
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Vancomycin / therapeutic use*
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Vancomycin Resistance / genetics
Substances
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Bacterial Proteins
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Carrier Proteins
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Penicillin-Binding Proteins
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Vancomycin
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase
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Methicillin