The chemotherapy at home is most different from the conventional chemotherapy because of the condition not to watch patients all the time. In order to avoid serious side effect it is necessary to administrate some drugs continuously or together. It is useful to use portable pump system. It is also important to educate patients about the chemotherapy at home and to establish the observation system against the trouble from the chemotherapy at home. As the chemotherapy at home is safe if we know the side effect well, this type of chemotherapy will become the one of main branch in the chemotherapy of colorectal cancer.