Getting to know the most important environmental risk factors for endometrial cancer development lets us provide well programmed primary preventive activity, thus avoiding or greatly reducing environmental risk factors for diseases. This activity may lead to a reduced number of new cases of endometrial cancer. We can help women live longer and better by well programmed preventive activity even when medical knowledge has reached such a high level of development. The authors analysed environmental risk factors for endometrial cancer development based on international medical references. The aim of our work was to review the environmental risk factors for endometrial cancer development which provoke initiation of the disease, sometimes change the clinical stage of the disease and influence medical treatment.