Abstract
Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3beta-hydroxy-5alpha-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Apocynaceae / chemistry*
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Cell Survival / drug effects
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Drug Resistance, Neoplasm
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Pregnanes / chemistry
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Pregnanes / isolation & purification*
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Pregnanes / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Plant Extracts
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Pregnanes
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wrightiamine A
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wrightiamine B